Macular maldevelopment in ATF6-mediated retinal dysfunction
نویسندگان
چکیده
منابع مشابه
ATF6 modulates SREBP2-mediated lipogenesis.
Activating transcription factor 6 (ATF6) and sterol regulatory element-binding proteins (SREBPs) are activated by proteolytic cleavage. The ensuing nuclear translocation of their N-termini (i.e., ATF6(N) and SREBP(N)) activates the respective target genes involved in unfolded protein response and lipogenesis. Here, we report that glucose deprivation activated ATF6 but suppressed the SREBP2-regu...
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Background and Objective: Diabetic macular edema (DME) is one of the common complications of diabetes which significantly accounts for preventable visual impairment and blindness. Central macular thickness (CMT) is a feature found in DME patients. This study aims to determine the relationship between optical coherence tomography (OCT)-measured CMT and visual acuity (VA) in patients with DME bef...
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ژورنال
عنوان ژورنال: Ophthalmic Genetics
سال: 2019
ISSN: 1381-6810,1744-5094
DOI: 10.1080/13816810.2019.1706749